The key is getting a video card new enough to have supported Win10 drivers. I also considered the M5A97 board (LE edition might be OK, but I was looking for the non-LE) and it would probably work well also. I am very happy with this upgrade and compared to all the time I spent screwing around with 'hardware acceleration' settings, trying to find the right video driver, etc., now my upgraded box works awesome with Windows 10, all video plays no problem, with proper video and audio. I should mention I also installed a higher wattage power supply, a 600W unit with the 8-pin CPU power plug.

No more video 'green screen' problems or missing audio. drivers from the M5A99FX CD, and now everything works great. Then I installed the latest drivers for the newer ASUS video card, installed the other chipset, etc. The existing Windows 10 installation on my 500GB SSD handled the new hardware fine, and booted up fine. onto the M5A99FX, and added an ASUS Radeon R9 270 video card. The process got so frustrating that I got rid of that motherboard and replaced it with an ASUS M5A99FX, and transferred my FX-8350 CPU, all my drives, RAM, network cards, etc. What I found is that the motherboard's onboard video, I believe a Radeon 4250, does not really have Windows 10 compatible drivers. (I didn't move to Windows 8 on this system) All of this stuff worked great on the exact same hardware under Windows 7. Some videos would work, and some would display green screens and sound, others would display video but no sound, and it was just maddening. I was using the motherboard's onboard Radeon HD4290 video. Mostly the problems involved video and audio, and in particular on YouTube within different browsers. I had all kinds of problems with my Asus MB M4A89GTD PRO/USB3 system on Windows 10.

M4a88t m usb3 review